Anti-NCAM-L1 antibody
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概述
- 产品描述The neural cell adhesion molecule L1 (NCAM-L1) is an immunoglobulin superfamily adhesion molecule that is critical for neural development, involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Defects in L1CAM are the cause of hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS). Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. Defects in L1CAM are also the cause of mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome (MASA), a X-linked disorder.
- 产品名称Anti-NCAM-L1 antibody
- 分子量220kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Synthetic peptide (KLH-coupled) corresponding to a region of C-terminal residues of NCAM-L1.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Cell membrane. Cell projection. Membrane.
- 数据链接P32004 Human
P11627 Mouse
- 其它名称Antigen identified by monoclonal antibody
R1 antibody
CAML1 antibody
CD171 antibody
CD171 antigen antibody
HSAS antibody
HSAS1 antibody
Hyd antibody
L1 antibody
L1 cell adhesion molecule antibody
L1-NCAM antibody
L1cam antibody
L1CAM_HUMAN antibody
MASA antibody
MIC5 antibody
N CAML1 antibody
N-CAM-L1 antibody
NCAM-L1 antibody
NCAML1 antibody
Nerve-growth factor-inducible large external glycoprotein antibody
Neural cell adhesion molecule L1 antibody
NILE antibody
OTTHUMP00000025992 antibody
S10 antibody
SPG1 antibody
more
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应用
WB: 1:500-1:1,000
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis of NCAML1 on human fetal brain tissue lysate using anti-NCAML1 antibody at 1/1,000 dilution.
Fig2: ICC staining NCAML1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining NCAML1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-NCAML1 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-NCAML1 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-NCAML1 antibody. Counter stained with hematoxylin.
Fig7: Flow cytometric analysis of SHG-44 cells with NCAML1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the second
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