Anti-HER2 / ErbB2 antibody
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概述
- 产品描述HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approx. 30% of breast cancer patients. Over-expression is also known to occur in ovarian, stomach, and aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. The expression of HER2 is regulated by signaling through estrogen receptors. Normally, estradiol and tamoxifen acting through the estrogen receptor down-regulate the expression of HER2. However, when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant breast cancer.
- 产品名称Anti-HER2 / ErbB2 antibody
- 分子量140kDa
- 种属反应性Human
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Cell membrane
- 其它名称Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
C erb B2/neu protein antibody
CD340 antibody
CD340 antigen antibody
Cerb B2/neu protein antibody
CerbB2 antibody
Erb b2 receptor tyrosine kinase 2 antibody
ERBB2 antibody
ERBB2_HUMAN antibody
HER 2 antibody
HER 2/NEU antibody
HER2 antibody
Herstatin antibody
Human epidermal growth factor receptor 2 antibody
Metastatic lymph node gene 19 protein antibody
MLN 19 antibody
MLN19 antibody
NEU antibody
NEU proto oncogene antibody
Neuro/glioblastoma derived oncogene homolog antibody
Neuroblastoma/glioblastoma derived oncogene homolog antibody
NGL antibody
p185erbB2 antibody
Proto-oncogene c-ErbB-2 antibody
Proto-oncogene Neu antibody
Receptor tyrosine-protein kinase erbB-2 antibody
TKR1 antibody
Tyrosine kinase type cell surface receptor HER2 antibody
Tyrosine kinase-type cell surface receptor HER2 antibody
V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody
V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody
V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody
V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody
V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody
more
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应用
WB: 1:500-1:1,000
ICC: 1:200
IHC-P: 1:200
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Fig1: Western blot analysis of ErbB2 on different cell lysates using anti- ErbB2 antibody at 1/500 dilution.
Positive control:
Lane 1: SKOV-3
Lane 2: SKBR-3
Fig2: ICC staining ErbB2 in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach carcinoma tissue using anti-Her 2 antibody. Counter stained with hematoxylin.
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