Anti-Spectrin (alpha + beta) antibody
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概述
- 产品描述Spectrin alpha chain, erythrocyte is a protein that in humans is encoded by the SPTA1 gene. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
- 产品名称Anti-Spectrin (alpha + beta) antibody
- 分子量280 KDa
- 种属反应性Human,Mouse,Rat,Pig,Horse,Rabbit
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from Human Spectrin alpha chain, erythrocytic 1 2151-2350/2419
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A.
- 亚细胞定位Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
- 其它名称Spectrin alpha chain, erythrocytic 1
Alpha I spectrin
EL 2
EL2
Elliptocytosis 2
Elliptocytosis2
Erythrocyte alpha spectrin
erythrocyte
Erythroid alpha spectrin
Erythroid alpha-spectrin
Erythroid spectrin alpha
HPP
HS3
Spectrin alpha chain
Spectrin alpha chain erythrocyte
Spectrin alpha erythrocytic 1
SPH3
SPTA 1
SPTA
SPTA1
SPTA1_HUMAN
Spectrin alpha chain, erythrocytic 1.
more
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Fig1: Sample:
Blood cell(Mouse) Lysate at 40 ug
Primary: Anti-Spectrin (alpha + beta) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 280 kD
Observed band size: 280 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
