Anti-PSK-H1 antibody
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概述
- 产品描述catalytic activity:ATP + a protein = ADP + a phosphoprotein. enzyme regulation:Activity depends on Ca(2+) concentration. May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. PTM:Autophosphorylated on serine residues. PTM:Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur. PTM:Palmitoylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain. subcellular location:Localized in the Brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes. subunit:Homodimer. tissue specificity:Expressed in all tissues and cell lines tested with the highest level of abundance in testis.
- 产品名称Anti-PSK-H1 antibody
- 分子量48 kDa
- 种属反应性Human, Mouse
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human KPSH1. AA range:261-310
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- PSKH1 antibody; Serine/threonine-protein kinase H1 antibody; Protein serine kinase H1 antibody; PSK-H1 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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Fig1: Western Blot analysis of various cells using PSK-H1 Polyclonal Antibody
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
