Anti-CYFIP2 antibody
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概述
- 产品描述disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level). Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA. induction:By p53. RNA editing:Partially edited. Editing appears to be brain-specific. Belongs to the CYFIP family. subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.
- 产品名称Anti-CYFIP2 antibody
- 分子量150/45 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) antibody;
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Fig1: Western Blot analysis of HEPG2 Hela cells using CYFIP2 Polyclonal Antibody diluted at 1:500. Secondary antibody（catalog#：HA1001) was diluted at 1:20000
Fig2: Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
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