Anti-FAK antibody
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概述
- 产品描述Focal adhesion kinase was initially identified as a major substrate for the intrinsic protein tyrosine kinase activity of Src encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase whose sequence and structural organization are unique as compared to other proteins described to date. Localization of p125 by immunofluorescence suggests that it is primarily found in cellular focal adhesions leading to its designation as focal adhesion kinase (FAK). FAK is concentrated at the basal edge of only those basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds and is activated and localized to the focal adhesions of spreading keratinocytes in culture. Thus, it has been postulated that FAK may have an important in vivo role in the reepithelialization of human wounds. FAK protein tyrosine kinase activity has also been shown to increase in cells stimulated to grow by use of mitogenic neuropeptides or neurotransmitters acting through G protein-coupled receptors.
- 产品名称Anti-FAK antibody
- 分子量125 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IP,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cytoplasm, Cell junction Cell membrane, Nucleus
- 其它名称
- FADK 1 antibody
- FADK antibody
- FAK related non kinase polypeptide antibody
more
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应用
WB: 1:1,000
IP: 1-2 μg per 100-500 μg of total protein
ICC: 1:50-500
IHC-P: 1:50-500
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Fig1: A.Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic staining of urothelial cells
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
