Anti-Ku70 antibody

Anti-Ku70 antibody

• 概述

• 产品描述Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.
• 产品名称Anti-Ku70 antibody [D1-A6]
• 分子量70 kDa
• 种属反应性Human,Mouse
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2a
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus
• 其它名称
  • 5'-deoxyribose-5-phosphate lyase Ku70 antibody
  • 5'-dRP lyase Ku70 antibody
  • 70 kDa subunit of Ku antigen antibody
  more

• 应用

  WB: 1:2,000
  IHC-P: 1:100-1:200

•  

  

  Fig1: Western blot analysis of Ku70 on different cell lysates using anti-Ku70 antibody at 1/2000 dilution.
  Positive control:
  Lane 1: Hela
  Lane 2: HepG2
  Lane 3: A431
  Lane 4: D3
  Lane 5: 293T
  Lane 6: A549
  Lane 7: COS-1
  Lane 8: Human kidney
  Lane 9: Human liver
  Lane 10: human brain
  Lane 11: Human thymus
  Lane 12: Human placentae
  Lane 13: Mouse kidney
  Lane 14: Mouse liver
  Lane 15: Mouse thymus
  Lane 16: Mouse testis

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Ku70 antibody. Counter stained with hematoxylin.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Ku70 antibody. Counter stained with hematoxylin.

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