Anti-MDR1 antibody [1G6]

Anti-MDR1 antibody [1G6] 

• 概述

• 产品描述Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.
• 产品名称Anti-MDR1 antibody [1G6]
• 分子量170 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原Mdr of hamster origin.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cell membrane
• 其它名称
  • ABC20 antibody
  • ABCB1 antibody
  • ATP binding cassette, sub family B (MDR/TAP), member 1 antibody
  more

• 应用

  WB: 1:10-1:200
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:10-1:200
  IHC-P: 1:10-1:200

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！