Anti-ALDH2 antibody [E4-D10]

Anti-ALDH2 antibody [E4-D10]

• 概述

• 产品描述Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizzes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.
• 产品名称Anti-ALDH2 antibody [E4-D10]
• 分子量56 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,ICC/IF,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Mitochondrion matrix
• 其它名称
  • Acetaldehyde dehydrogenase 2 antibody
  • Aldehyde dehydrogenase 2 family (mitochondrial) antibody
  • Aldehyde dehydrogenase 2 family antibody
  more

• 应用

  WB: 1:1,000-1:5,000
  ICC/IF: 1:50-1:200
  IHC-P: 1:50-1:200
  FC: 1:50-1:100

•  

  

  Fig1: Western blot analysis on HepG2 cells lysates using anti-ALDH2 Mouse mAb.

   

  

  Fig2: Immunocytochemical staining of HepG2 cells using anti-ALDH2 Mouse mAb.

   

  

  Fig3: Immunocytochemical staining of PC-3M cells using anti-ALDH2 Mouse mAb.

   

  

  Fig4: Immunohistochemical analysis of paraffin- embedded human lung cancer tissue using anti-ALDH2 Mouse mAb.

   

  

  Fig5: Immunohistochemical analysis of paraffin- embedded human liver cancer tissue using anti-ALDH2 Mouse mAb.

   

  

  Fig6: Immunohistochemical analysis of paraffin- embedded human colon cancer tissue using anti-ALDH2 Mouse mAb.

   

  

  Fig7: Immunohistochemical analysis of paraffin- embedded human gastric cancer tissue using anti-ALDH2 Mouse mAb.

   

  

  Fig8: Immunohistochemical analysis of paraffin- embedded mouse colon tissue using anti-ALDH2 Mouse mAb.

   

  

  Fig9: Immunohistochemical analysis of paraffin- embedded mouse stomach tissue using anti-ALDH2 Mouse mAb.

   

  

  Fig10: Flow cytometric analysis of HepG2 cells with ALDH2 antibody at 1/100 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary

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