Anti-CIRBP antibody [B3-E12]

Anti-CIRBP antibody [B3-E12]

• 概述

• 产品描述Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
• 产品名称Anti-CIRBP antibody [B3-E12]
• 分子量19 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus. Cytoplasm.
• 其它名称
  • A18 hnRNP antibody
  • A18HNRNP antibody
  • cirbp antibody
  more

• 应用

  WB: 1:500-1:1,000
  IHC-P: 1:50-1:200

•  

  

  Fig1: Western blot analysis of CIRBP on human CIRBP recombinant protein using anti-CIRBP antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of CIRBP on HEK293 (1) and CIRBP-hIgGFc transfected HEK293 (2) cell lysate using anti-CIRBP antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of CIRBP on different cell lysate using anti-CIRBP antibody at 1/1,000 dilution.
  Positive control: Line1: SW480 Line2: PC-3 Line3: A431 Line4: U251

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human bladder cancer tissue using anti-CIRBP antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-CIRBP antibody. Counter stained with hematoxylin.

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