Anti-HLA E antibody [4G23]

Anti-HLA E antibody [4G23]

• 概述

• 产品描述Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an α or heavy chain and a non-covalently associated pro- tein, β-2-Microglobulin. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encod- ed by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralog. HLA-E is a heterodimer consisting of a heavy chain and a light chain; the heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.
• 产品名称Anti-HLA E antibody [4G23]
• 分子量40kDa
• 种属反应性Human
• 验证应用WB,IP
• 抗体类型小鼠单抗
• 免疫原Recombinant HLA-E of human origin
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane
• 其它名称
  • HLA class I histocompatibility antigen E alpha chain antibody
  • EA1.2 antibody
  • EA2.1 antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) FCM: 1 μg per 1 x 106 cells

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  Fig1: Western blot analysis of HLA-E expression in human PBL (A), BJAB (B), CCRF- CEM (C) and AML-193 (D) whole cell lysates.

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