Anti-Serum Amyloid A (SAA) antibody [4G08]

Anti-Serum Amyloid A (SAA) antibody [4G08]

• 概述

• 产品描述The serum Amyloid A (SAA) family of proteins is encoded by muliple genes, which display allelic variation and a high degree of homology in mammals. The four members of the SAA gene family are clustered on human chromo- some 11p15.1. Three SAA genes are differentially expressed and encode small apolipoproteins. SAA1 and SAA2 encode the acute phase SAAs (A-SAAs) and SAA4 encodes the constitutively expressed SAA (C-SAA). A fourth locus, SAA3, is a pseudogene that contains two C/EBP-binding sites and a third site, which interacts with SAA3 enhancer factor . Human SAA proteins are a group of apolipoproteins found predominantly in the high-density lipoprotein (HDL) fraction of plasma. SAA is a major acute-phase protein and precursor to Amyloid A protein, which is the major constituent of the fibril deposits of reactive amyloidosis. SAA is secreted in large amounts by the liver during microbial infections or inflammatory diseases.
• 产品名称Anti-Serum Amyloid A (SAA) antibody [4G08]
• 分子量12kDa
• 种属反应性Human
• 验证应用WB, IP
• 抗体类型小鼠单抗
• 免疫原Highly purified recombinant SAA of human origin
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃.
• 存储缓冲液1*TBS (pH7.4), 1%BSA. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted
• 其它名称
  • Amyloid fibril protein AA antibody
  • Amyloid fibrils antibody
  • Amyloid protein A antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

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  Fig1: Western blot analysis of human recombinant SAA.

   

  

  Fig2: Western blot analysis of SAA expression in Caki-1 whole cell lysate (A) and of SAA human plasma (B).

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