ClinMax™Human Interleukin 1 beta (IL-1 beta) Quantitative ELISA Kit

ClinMax™Human Interleukin 1 beta (IL-1 beta) Quantitative ELISA Kit

Background/背景

ClinMax™Human IL-1β Quantitative ELISA Kit is designed to quantitate human IL-1β that is present in complex biological matrices, such as human serum, plasma, buffered solution, or cell culture. Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine. IL-1β is produced and secreted by various cell types, such as immune cells, fibroblasts, or cancer cells. The IL-1β gene is induced after "priming" of the cells and a second signal is required to allow IL-1β maturation by inflammasome-activated caspase-1. IL-1β is then released and leads to transcription of target genes through its ligation with IL-1R1 on target cells. IL-1β expression and maturation are guided by gene polymorphisms and by the cellular context. In cancer, IL-1β has pleiotropic effects on immune cells, angiogenesis, cancer cell proliferation, migration, and metastasis.

Application/应用

This immunoassay is designed to quantitate human IL-1β that is present in human serum, plasma, buffered solution, or cell culture. It has been calibrated against a highly purified human IL-1β and is evaluated with standard from NIBSC/WHO. Reference Reagent Interleukin-1β (Human, rDNA derived) NIBSC code: 86/680.

It is for research use only.

Storage/存储

The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

 

 

Assay Principles/原理

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！