Anti-PHF10 antibody
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概述
- 产品描述Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
- 产品名称Anti-PHF10 antibody
- 分子量56 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P
- 抗体类型兔多抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified
- 亚细胞定位Nucleus.
- 其它名称BAF45a antibody
BRG1-associated factor 45a antibody
FLJ10975 antibody
MGC111009 antibody
PHD finger protein 10 antibody
PHD finger protein 10, isoform a antibody
PHD zinc finger protein XAP135 antibody
Phf10 antibody
PHF10_HUMAN antibody
XAP135 antibody
more
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应用
WB: 1:500-1:1,000
IHC-P: 1:50-1:200
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Fig1: Western blot analysis of PHF10 on Hela cell lysate using anti-PHF10 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-PHF10 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PHF10 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-PHF10 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PHF10 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-PHF10 antibody. Counter stained with hematoxylin.
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