Anti-PRTN3 antibody
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概述
- 产品描述The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19.
- 产品名称Anti-PRTN3 antibody
- 分子量27 kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein A purified.
- 亚细胞定位Cytoplasm.
- 其它名称ACPA antibody
AGP 7 antibody
AGP7 antibody
AGP7 serine proteinase antibody
Azurophil Granule Protein 7 antibody
C ANCA antibody
C ANCA antigen antibody
C-ANCA antigen antibody
CANCA antibody
EC 3.4.21.76 antibody
Leukocyte proteinase 3 antibody
MBN antibody
MBT antibody
MBT WEGENER AUTOANTIGEN antibody
Myeloblastin antibody
Neutrophil proteinase 4 antibody
NP 4 antibody
NP-4 antibody
NP4 antibody
P29 antibody
PR 3 antibody
PR-3 antibody
PR3 antibody
Proteinase 3 antibody
Proteinase3 antibody
PRTN 3 antibody
Prtn3 antibody
PRTN3_HUMAN antibody
Serine proteinase neutrophil Wegener granulomatosis autoantigen antibody
Serine proteinase, neutrophil antibody
Wegener autoantigen antibody
Wegener granulomatosis autoantigen antibody
more
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应用
WB: 1:500
ICC: 1:50-1:200
IHC-P: 1:100-1:500
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Fig1: Western blot analysis of PRTN3 on U937 using anti-PRTN3 antibody at 1/500 dilution.
Fig2: Western blot analysis of PRTN3 on mouse marrow lysate using anti-PRTN3 antibody at 1/100 dilution.
Fig3: ICC staining PRTN3 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: ICC staining PRTN3 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig5: ICC staining PRTN3 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig6: Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-PRTN3 antibody. Counter stained with hematoxylin.
Fig7: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-PRTN3 antibody. Counter stained with hematoxylin.
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