Anti-ALOX12 antibody
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概述
- 产品描述Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750,
- 产品名称Anti-ALOX12 antibody
- 分子量76 KDa
- 种属反应性Human,Mouse,Rat,Cow
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human 12 Lipoxygenase 101-200/663
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
- 其它名称12 Lox
12(S) lipoxygenase
12S LOX
Alox 12
Alox12L
Alox15
Arachidonate 12 lipoxygenase 12S type
Arachidonate 12 lipoxygenase
Arachidonate 12 lipoxygenase leukocyte type
Arachidonate 12 lipoxygenase, 12S type
Arachidonate 12 lipoxygenase, leukocyte type
EC1.13.11.31
LOG 12
LOG12
Platelet type 12 lipoxygenase
Platelet type lipoxygenase 12
P-12-LOX
LOX12_HUMAN
12 Lipoxygenase.
more
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Fig1: Sample:
Raw264.7 Cell Lysate at 40 ug
A431 Cell Lysate at 40 ug
Primary: Anti-ALOX1at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 73 kD
Observed band size: 73 kD
特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!