Anti-CEAcam8 antibody
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概述
- 产品描述The carcino-embryonic antigen-related cell adhesion molecule (CEACAM)8, often better known as CD66b, encodes a glycosylphosphatidylinositol (GPI)-linked glycoprotein, which is exclusively expressed by human granulocytes. CEACAM8 belongs to the carcinoembryonic antigen (CEA) family of the immunoglobulin superfamily. CEACAMs are involved in various intercellular-adhesion and cellular signaling-mediated effects modulating immune responses which are associated with the binding of pathogens, inflammation as well as growth and/or differentiation of normal and cancerous cells. CEACAM8 is stored in specific vesicles of granulocytes and acts as a marker for specific vesicles for exocytosis [8]. Secretion has been shown to be induced by Phorbol-12-myristate-13-acetate (PMA). Interestingly, no homolog for CEACAM8 has been identified in rodents, suggesting that there may be a strong selection pressure (e.g., exposure to microorganisms or parasites) during the evolution of molecules of the CEA family. The soluble form of CEACAM8 binds to CEACAM1, a trans-membrane-bound molecule expressed by certain normal epithelial, endothelial, different leukocyte subpopulations and some cancer cells.
- 产品名称Anti-CEAcam8 antibody
- 分子量38 KDa
- 种属反应性Human
- 验证应用WB,IHC-P
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human CEAcam8 51-150/349
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Cell membrane; Lipid-anchor, GPI-anchor.
- 其它名称Carcinoembryonic Antigen CGM6
Carcinoembryonic antigen gene family member 6
Carcinoembryonic Antigen Related Cell Adhesion Molecule 8
CD 66b
CD 67
CD66b antigen
CD67
CD67 antigen
CEACAM 8
CEACAM8
CGM 6
CGM6
NCA 95
NCA95
Nonspecific cross reacting antigen NCA 95
Non-specific -reacting antigen NCA-95
Nonspecific cross reacting antigen NCA95
CEAM8_HUMAN
Carcinoembryonic antigen-related cell adhesion molecule 8
CD66b.
more
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应用
WB:1:500-2000
IHC-P:1:400-800
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Fig1: Sample:
HL-60(Human) Cell Lysate at 40 ug
Primary: Anti-CEAcam8at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38 kD
Observed band size: 75 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
