Anti-Cleaved-C1r HC (R463) antibody
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概述
- 产品描述catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3. 4. 21. 42). C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. polymorphism:Complement component C1r deficiency leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE). PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Belongs to the peptidase S1 family. Contains 1 EGF-like domain. Contains 1 peptidase S1 domain. Contains 2 CUB domains. Contains 2 Sushi (CCP/SCR) domains. subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.
- 产品名称Anti-Cleaved-C1r HC (R463) antibody
- 分子量51 kDa
- 种属反应性Human
- 验证应用WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human C1R. AA range:414-463
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 亚细胞定位Secreted.
- 其它名称C1R antibody
Complement C1r subcomponent antibody
Complement component 1 subcomponent r antibody
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Fig1: Western blot analysis of C1R (heavy chain, Cleaved-Arg463) Antibody. The lane on the right is blocked with the C1R (heavy chain, Cleaved-Arg463) peptide.
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