Anti-CDA7Lantibody
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概述
- 产品描述Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line. miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation. subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. subunit:Interacts with MYC and PSIP1. tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.
- 产品名称Anti-CDA7L antibody
- 分子量49 kDa
- 种属反应性Human
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from human protein . at AA range: 140-220
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
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特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!