Anti-TNR18 antibody

Anti-TNR18 antibody

• 概述

• 产品描述TNFRSF18 is a member of the tumor necrosis factor receptor (TNF-R) superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25+/CD4+ regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules in the pathogenesis of autoimmune diseases. Despite the importance of these costimulatory molecules in autoimmune disease, their role in the autoimmune reaction to herniated disc fragments has yet to be explored. GITR was identified as a new member of the TNF receptor superfamily, by comparing gene expression in untreated and DEX-treated murine T-cell lines. GITR can also be induced when T cells are activated. Although mouse GITR is induced by either GC engagement or T-cell activation, its human homologue (hGITR/AITR) is upregulated only by activation. Therefore, the requirements for GR signaling in inducing GITR expression by T cells remain moot .
• 产品名称Anti-TNR18 antibody
• 分子量26 kDa
• 种属反应性Human
• 验证应用WB
• 抗体类型兔多抗
• 免疫原Synthesized peptide derived from part region of human protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度1 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
• 亚型IgG
• 纯化方式Immunogen affinity purified.
• 亚细胞定位Cell membrane, Secreted.
• 其它名称Activation inducible TNFR family receptor antibody
  Activation-inducible TNFR family receptor antibody
  AITR antibody
  CD357 antibody
  GITR antibody
  GITR D antibody
  GITR-D antibody
  GITRD antibody
  Glucocorticoid induced TNFR related protein antibody
  glucocorticoid-induced tnf receptor ligand antibody
  glucocorticoid-induced tnf receptors ligand antibody
  Glucocorticoid-induced TNFR-related protein antibody
  TNF receptor superfamily activation inducible protein antibody
  TNFRSF 18 antibody
  TNFRSF18 antibody
  TNR18_HUMAN antibody
  Tumor necrosis factor receptor superfamily member 18 antibody
  Tumor necrosis factor receptor superfamily member 18 precursor antibody
  more

• 应用

  WB: 1:500-1:2000

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！