Anti-Abl1/2 antibody
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概述
- 产品描述This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
- 产品名称Anti-Abl1/2 antibody
- 分子量125(200kd BCR-ABL complex） kDa
- 种属反应性Human, Mouse
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human c-Abl. AA range:406-455
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称ABL1 antibody; ABL antibody; JTK7 antibody; Tyrosine-protein kinase ABL1 antibody; Abelson murine leukemia viral oncogene homolog 1 antibody; Abelson tyrosine-protein kinase 1 antibody; Proto-oncogene c-Abl antibody; p150 antibody; ABL2 antibody; ABLL antibody; ARG antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson murine leukemia vira antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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Fig1: Western Blot analysis of various cells using Abl1/2 Polyclonal Antibody
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