Anti-AF-4 antibody
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概述
- 产品描述This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
- 产品名称Anti-AF-4 antibody
- 分子量130 kDa
- 种属反应性Human,Mouse
- 验证应用IHC-P,WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称AFF1 antibody; AF4 antibody; FEL antibody; MLLT2 antibody; PBM1 antibody; AF4/FMR2 family member 1 antibody; ALL1-fused gene from chromosome 4 protein antibody; Protein AF-4 antibody; Protein FEL antibody; Proto-oncogene AF4 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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