Anti-Dok-4 antibody
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概述
- 产品描述domain:PTB domain mediates receptor interaction. DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. PTM:Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. Belongs to the DOK family. Type B subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain. subunit:Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062'. tissue specificity:Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
- 产品名称Anti-Dok-4 antibody
- 分子量37 kDa
- 种属反应性Human, Mouse
- 验证应用WB, IHC-P, IF
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human DOK4. AA range:11-60
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称DOK4 antibody; Docking protein 4 antibody; Downstream of tyrosine kinase 4 antibody; Insulin receptor substrate 5 antibody; IRS-5 antibody; IRS5 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
IF: 1:100-1:500
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Fig1: Western Blot analysis of various cells using Dok-4 Polyclonal Antibody
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
