Anti-NDR2 antibody
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概述
- 产品描述catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. Involved in the regulation of structural processes in differentiating and mature neuronal cells. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. subcellular location:Associated with the actin cytoskeleton. subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2. tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.
- 产品名称Anti-NDR2 antibody
- 分子量54 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from NDR2 . at AA range: 380-460
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称STK38L antibody; KIAA0965 antibody; NDR2 antibody; Serine/threonine-protein kinase 38-like antibody; NDR2 protein kinase antibody; Nuclear Dbf2-related kinase 2 antibody;
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应用
WB: 1:500-1:2000
IHC-P:1:50-300
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Fig1: Western Blot analysis of mouse cells using NDR2 Polyclonal Antibody
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