Anti-p40-phox antibody
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概述
- 产品描述The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d
- 产品名称Anti-p40-phox antibody
- 分子量40 kDa
- 种属反应性Human,Mouse
- 验证应用IHC-P,WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human p40 phox. AA range:120-169
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- NCF4 antibody; SH3PXD4 antibody; Neutrophil cytosol factor 4 antibody; NCF-4 antibody; Neutrophil NADPH oxidase factor 4 antibody; SH3 and PX domain-containing protein 4 antibody; p40-phox antibody; p40phox antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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