Anti-Lck BP-1 antibody
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概述
- 产品描述developmental stage:Expressed in early stage of myeloid and erythroid differentiation. Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. Contains 1 SH3 domain. Contains 4 cortactin repeats. subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. tissue specificity:Expressed only in tissues and cells of hematopoietic origin.
- 产品名称Anti-Lck BP-1 antibody
- 分子量54 kDa
- 种属反应性Human
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from Lck BP-1 . at AA range: 340-420
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- HCLS1 antibody; HS1 antibody; Hematopoietic lineage cell-specific protein antibody; Hematopoietic cell-specific LYN substrate 1 antibody; LckBP1 antibody; p75 antibody;
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