Anti-CD328 antibody
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概述
- 产品描述domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). online information:Siglec-7,PTM:Tyrosine phosphorylated. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. subunit:Interacts with PTPN6/SHP-1 upon phosphorylation. tissue specificity:Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
- 产品名称Anti-CD328 antibody
- 分子量51 kDa
- 种属反应性Human
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC7. AA range:51-100
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- SIGLEC7 antibody; AIRM1 antibody; Sialic acid-binding Ig-like lectin 7 antibody; Siglec-7 antibody; Adhesion inhibitory receptor molecule 1 antibody; AIRM-1 antibody; CDw328 antibody; D-siglec antibody; QA79 membrane protein antibody; p75 antibody; CD328 antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-300
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Fig1: Western Blot analysis of K562 cells using CD328 Polyclonal Antibody.. Secondary antibody（catalog#：HA1001) was diluted at 1:20000
Fig2: Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:100
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