Anti-Tensin3 antibody
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概述
- 产品描述May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development. induction:EGF induces down-regulation. PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner. Contains 1 C2 tensin-type domain. Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain. subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions. tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
- 产品名称Anti-Tensin3 antibody
- 种属反应性Human
- 验证应用IHC-P,IF
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- TNS3 antibody; TEM6 antibody; TENS1 antibody; TPP antibody; Tensin-3 antibody; Tensin-like SH2 domain-containing protein 1 antibody; Tumor endothelial marker 6 antibody;
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应用
IHC-P: 1:100-1:300
IF: 1:100-1:500
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