Anti-FPR2 antibody
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概述
- 产品描述The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR2 (also designated lipoxin A4 receptor, FPRH1 and FPRL1) and FPR3 (also designated FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR2 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of ∫ amyloid. Upon activation, FPR2 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR2 may mediate inflammation in prion and Alzheimer’s diseases, which makes it a potential target for therapeutic agents.
- 产品名称Anti-FPR2 antibody
- 分子量39 kDa
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种属反应性Human,Mouse,Rat
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验证应用ICC,IHC-P,FC
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抗体类型兔多抗
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免疫原peptide
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偶联Non-conjugated
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性能
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形态Liquid
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浓度1 mg/mL.
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存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
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存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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亚型IgG
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纯化方式Peptide affinity purified
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亚细胞定位Cell membrane
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其它名称
more
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ALXR antibody
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FMLP-R-I antibody
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FMLP-R-II antibody
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应用
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Immunocytochemical staining of Hela cells using anti-FPR2 rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of PC-3M cells using anti-FPR2 rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of HepG2 cells using anti-FPR2 rabbit polyclonal antibody.
Fig4: Immunohistochemical analysis of paraffin- embedded human lung cancer tissue using anti-FPR2 rabbit polyclonal antibody.
Fig5: Immunohistochemical analysis of paraffin- embedded human spleen tissue using anti-FPR2 rabbit polyclonal antibody.
Fig6: Immunohistochemical analysis of paraffin- embedded mouse testis tissue using anti-FPR2 rabbit polyclonal antibody.
Fig7: Flow cytometric analysis of Jurkat cells with FPR2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary
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