Anti-HMGB1 antibody
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概述
- 产品描述Like the histones, HMGB1, also known as high-mobility group protein 1 (HMG-1) is among the most important chromatin proteins. In the nucleus HMGB1 interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription. After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. HMGB1 is secreted by immune cells (like macrophages, monocytes and dendritic cells) through leaderless secretory pathway. Activated macrophages and monocytes secrete HMGB1 as a cytokine mediator of Inflammation. In recent research, HMGB1 has been reported as a novel biomarker for human ovarian cancer.
- 产品名称Anti-HMGB1 antibody
- 分子量25 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Nucleus
- 其它名称
- Amphoterin antibody
- Chromosomal protein, nonhistone, HMG1 antibody
- DKFZp686A04236 antibody
more
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应用
WB: 1:1,000-1:2,000
ICC: 1:200-1:500
IHC-P: 1:200
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Fig1: Western blot analysis on MCF-7 (1), PC12 (2) and F9 (3) cell lysates using anti-HMGB1 rabbit polyclonal antibodies.
Fig2: Immunofluorescent staining of Hela cells using anti- HMGB1 rabbit polyclonal antibody.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- HMGB1 rabbit polyclonal antibody.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
