Anti-TSC2/Tuberin antibody
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概述
- 产品描述Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.
- 产品名称Anti-TSC2/Tuberin antibody
- 种属反应性Human,Mouse
- 验证应用ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Cytoplasm, Membrane
- 其它名称
- FLJ43106 antibody
- LAM antibody
- OTTHUMP00000158940 antibody
more
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应用
ICC: 1:100-1:500
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Immunocytochemical staining of SH-SY-5Y cells using anti-Tuberin rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of PANC-1 cells using anti-Tuberin rabbit polyclonal antibody.
Fig3: Immunohistochemical analysis of paraffin- embedded human pancreas tissue using anti-Tuberin rabbit polyclonal antibody.
Fig4: Immunohistochemical analysis of paraffin- embedded mouse liver tissue using anti-Tuberin rabbit polyclonal antibody.
Fig5: Immunohistochemical analysis of paraffin- embedded human liver tissue using anti-Tuberin rabbit polyclonal antibody.
Fig6: Immunohistochemical analysis of paraffin- embedded mouse pancreas tissue using anti-Tuberin rabbit polyclonal antibody.
Fig7: Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-Tuberin rabbit polyclonal antibody.
Fig8: Flow cytometric analysis of Hela cells with Tuberin antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary
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