Anti-BAX antibody
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概述
- 产品描述Bax is a key component for cellular induced apoptosis through mitochondrial stress. It accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, BAX undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. It promotes activation of CASP3, and thereby apoptosis.
- 产品名称Anti-BAX antibody
- 分子量21 kDa
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种属反应性Human,Mouse
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验证应用ICC,IHC-P
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抗体类型兔多抗
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免疫原Peptide-KLH
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偶联Non-conjugated
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性能
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形态Liquid
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浓度1 mg/mL.
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存放说明Store at +4℃after thawing. Aliquot store at -20℃or -80℃. Avoid repeated freeze / thaw cycles.
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存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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亚型IgG
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纯化方式Peptide affinity purified
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亚细胞定位Mitochondrion membrane, cytoplasm.
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其它名称
more
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应用
ICC: 1:100-1:200
IHC-P: 1:50-1:200
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Fig1: ICC staining BAX in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig2: ICC staining BAX in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-BAX antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-BAX antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-BAX antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-BAX antibody. Counter stained with hematoxylin
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