Anti-PSD95 antibody
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概述
- 产品描述PSD-95 is a member of the membrane-associated guanylate kinase(MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the?clustering of receptors, ion channels, and associated signaling proteins.PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density ofneurons,and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin,NMDA receptors,AMPA receptors, and potassium channels.It plays an important role in synaptic plasticity and the stabilization of synaptic changes during?long-term potentiation.
- 产品名称Anti-PSD95 antibody
- 分子量80kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P,FC
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Cell membrane
- 其它名称
- Discs large homolog 4 antibody
- Disks large homolog 4 antibody
- DLG 4 antibody
more
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应用
WB: 1:1000
IHC-P: 1:50
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Fig1: Western blot analysis on different cell lysates using anti- PSD95 rabbit polyclonal antibodies.
Fig2: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- PSD95 rabbit polyclonal antibody.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- PSD95 rabbit polyclonal antibody.
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