Anti-ALDH4A1 antibody [7E3]

Anti-ALDH4A1 antibody [7E3]

• 概述

• 产品描述Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.
• 产品名称Anti-ALDH4A1 antibody [7E3]
• 分子量62 kDa
• 种属反应性Human,Rat
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Synthetic peptide of C terminal human ALDH4A1.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein G purified.
• 亚细胞定位Mitochondrion.
• 其它名称
  • AL4A1_HUMAN antibody
  • aldehyde dehydrogenase 4 antibody
  • aldehyde dehydrogenase 4 family, member A1 antibody
  more

• 应用

  WB: 1:1,000-1:2,000
  IHC-P: 1:50-1:200

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  Fig1: Western blot analysis of ALDH4A1 on SK-Br-3 (1) and HepG2 (2) cell lysate using anti-ALDH4A1 antibody at 1/1,000 dilution.

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.

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