Anti-IMP3 antibody [4-C2-5]

Anti-IMP3 antibody [4-C2-5]

• 概述

• 产品描述RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
• 产品名称Anti-IMP3 antibody [4-C2-5]
• 分子量64kDa
• 种属反应性Human,Mouse
• 验证应用WB,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein within human IMP3 aa 350-650.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG
• 纯化方式ProG purified.
• 亚细胞定位Nucleus.
• 其它名称
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• 应用

  WB: 1:500-1:1,000
  FC: 1:50-1:100

•  

  

  Fig1: Western blot analysis of IMP3 on 293T cell lysate using anti-IMP3 antibody at 1/2,000 dilution.

   

  

  Fig2: Flow cytometric analysis of PANC-1 cells with IMP3 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-mouse IgG was used as the secondary antibody.

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