Anti-BACE1 antibody [7H4]

Anti-BACE1 antibody [7H4]

• 概述

• 产品描述Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the β-Amyloid protein precursor (APP). Amyloid β-peptide (Aβ), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by β- and γ-secretases. BACE is the transmembrane protease which cleaves Aβ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue, with the highest levels in the pancreas.BACE is localized within Golgi and endosomes.
• 产品名称Anti-BACE1 antibody [7H4]
• 分子量55.7 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane, Cytoplasmic vesicle membrane
• 其它名称
  • APP beta secretase antibody
  • Asp 2 antibody
  • ASP2 antibody
  more

• 应用

  WB: 1:1,000
  IP: 1-2 μg per 100-500 μg of total protein
  IF: 1:50-500
  IHC-P: 1:50-500

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  Fig1: A.Western blot analysis of BACE expression in SH-SY5Y whole cell lysate.

   

  

  Fig2: B.Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

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