Anti-SRY antibody [E9-G4]
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概述
- 产品描述SRY (sex-determining region Y protein) is a tran-scriptional activator required for male sex determination in mammals. This protein, also referred to as testis-determining factor (TDF), is an HMG box protein that initiates the formation of testis from undifferentiated gonad. The DNA-binding activity of SRY is required for normal testis formation. This DNA-binding activity is thought to be regulated by PKA, which phosphorylates SRY in vivo. Mutations in SRY have been associated with 46,XY gonadal dysgenesis, in which the gonads fail to develop in XY phenotypic females.
- 产品名称Anti-SRY antibody [E9-G4]
- 分子量40 kDa
- 种属反应性Human
- 验证应用WB,IHC-P,FC
- 抗体类型小鼠单抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
- 亚型IgG1
- 纯化方式Protein A purified.
- 亚细胞定位Nucleus speckle. Cytoplasm.
- 其它名称
- Essential protein for sex determination in human males antibody
- Sex determining region on Y antibody
- Sex determining region protein antibody
more
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应用
WB: 1:500-1:1,000
IHC-P: 1:100-1:500
FC: 1:100-1:200
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Fig1: Western blot analysis of SRY on human SRY recombinant protein using anti-SRY antibody at 1/1,000 dilution.
Fig2: Western blot analysis of SRY on NTERA-2 cell lysate using anti-SRY antibody at 1/1,000 dilution.
Fig3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-SRY antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-SRY antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of HepG2 cells with SRY antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
![Anti-SRY antibody [E9-G4]](images/202012/goods_img/92394_G_1607253098014.jpg)
