Anti-CRP antibody [E8-G1]

Anti-CRP antibody [E8-G1]

• 概述

• 产品描述C Reactive Protein(CRP) is produced by liver epithelial cells and is characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Stat3 is involved in mouse CRP gene expression. CRP bind to Fc g R and opsonize particles for phagocytosis by human polymorphonuclear leukocytes. Opsonization of zymosan by CRP is mediated through Fc g RI, while Fc g RII and Fc g RIII are receptors for SAP. Therefore, CRP and SAP play critical roles in the host defense system.
• 产品名称Anti-CRP antibody [E8-G1]
• 分子量25 kDa
• 种属反应性Human
• 验证应用WB,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted.
• 其它名称
  • Pentraxin 1, short antibody
  • C reactive protein antibody
  • C reactive protein pentraxin related antibody
  more

• 应用

  WB: 1:500-1:1,000
  IHC-P: 1:100-1:500
  FC: 1:100-1:200

•  

  

  Fig1: Western blot analysis of CRP on human CRP recombinant protein using anti-CRP antibody at 1/1,000 dilution.

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-CRP antibody. Counter stained with hematoxylin.

   

  

  Fig3: Flow cytometric analysis of MCF-7 cells with CRP antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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