Anti-BRCA1 antibody [D2-C6]

Anti-BRCA1 antibody [D2-C6]

• 概述

• 产品描述In 1990, a breast cancer susceptibility gene, designated BRCA1, was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino terminal region, but is otherwise unrelated to any previously described proteins. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth.
• 产品名称Anti-BRCA1 antibody [D2-C6]
• 分子量208 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm. Nucleus. Plasma Membrane.
• 其它名称
  • BRCA 1 antibody
  • BRCA1 antibody
  • BRCA1 DNA repair associated antibody
  more

• 应用

  WB: 1:500-1:1,000
  IHC-P: 1:100-1:500

•  

  

  Fig1: Western blot analysis of BRCA1 on human BRCA1 recombinant protein using anti-BRCA1 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of BRCA1 on HEK293 (1) and BRCA1-hIgGFc transfected HEK293 (2) cell lysate using anti-BRCA1 antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-BRCA1 antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human esophagus tissue using anti-BRCA1 antibody. Counter stained with hematoxylin.

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