Anti-NKX3A antibody [C3-H4]
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概述
- 产品描述The homeobox gene Nkx-3.1 is the human homolog of Drosophila bagpipe, which, in conjunction with tinman, determines cell fate in the dorsal mesoderm. In mammalian species, Nkx-3.1 is predominantly expressed in prostate, and it regulates prostate development in response to sonic hedgehog (Shh) signaling by exerting growth-suppressive and differentiating effects on prostatic epithelium. Nkx-3.1 is also expressed at lower levels in other tissues, including the heart and gut, in a Shh independent manner, where it plays a role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate and minor salivary glands. Nkx-3.1 preferentially binds the TAAGTA sequence, which has not been reported for any other NK class homeoprotein. The human Nkx-3.1 gene is located on chromosome 8q21, which frequently undergoes a loss of heterozygosity, and although Nkx-3.1 is not a tumor suppressor gene, it may be a useful marker for benign and malignant prostate epithelium.
- 产品名称Anti-NKX3A antibody [C3-H4]
- 分子量26 kDa
- 种属反应性Human
- 验证应用WB, IHC-P, FC
- 抗体类型小鼠单抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
- 亚型IgG2b
- 纯化方式Protein A purified.
- 亚细胞定位Nucleus.
- 其它名称
- BAPX 2 antibody
- BAPX2 antibody
- Homeobox protein NK-3 homolog A antibody
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应用
WB: 1:500-1:1,000
IHC-P: 1:50-1:200
FC: 1:100-1:200
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Fig1: Western blot analysis of NKX3A on LNCaP cell lysate using anti-NKX3A antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-NKX3A antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-NKX3A antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-NKX3A antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of PC-3 cells with NKX3A antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).
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