Anti-XAF1 antibody [2G1]

Anti-XAF1 antibody [2G1]

• 概述

• 产品描述X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) is azinc finger protein that blocks the anti-apoptotic activity of XIAP. XIAP is amember of the family of intrinsic inhibitors of apoptosis proteins (IAPs), whichsuppress apoptosis through the inhibition of caspases. In the presence ofXAF1, XIAP protein redistributes from the cytosol to the nucleus. XAF1 transcripts(3.9-, 4.5-, 6.0- and 7.0-kb) are present at high levels in heart and ovary.Low expression of XAF1 mRNA is an indicator for certain cancers (WM164melanoma, WM35 melanoma, U937 pro-monocytic leukemia and HT1080fibrosarcoma), suggesting that low levels of XAF1 transcript may enhancecancer cell-survival through the relative increase in XIAP anti-apoptotic function.IFN-α and IFN-β activate the human XAF1 gene, which maps to chromosome17p13.1.
• 产品名称Anti-XAF1 antibody [2G1]
• 分子量35 kDa
• 种属反应性Human
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原Amino acids 1-225 mapping at the N-terminus of XAF1 of human origin.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm, Nucleus, Mitochondrion
• 其它名称
  • BIRC 4 binding protein antibody
  • BIRC4 binding protein antibody
  • BIRC4-binding protein antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500

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  Fig1: Western blot analysis of XAF1 expression in non-transfected (A) and human XAF1 transfected (B) 293T whole cell lysates.

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