Anti-TdT antibody
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概述
- 产品描述Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1–3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals
- 产品名称Anti-TdT antibody
- 分子量58kDa
- 种属反应性Human
- 验证应用WB
- 抗体类型兔多抗
- 免疫原This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of human TdT.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cell nucleus
- 其它名称Deoxynucleotidyltransferase terminal antibody
DNA nucleotidylexotransferase antibody
DNTT antibody
Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody
TDT antibody
TDT_HUMAN antibody
Terminal addition enzyme antibody
Terminal deoxynucleotidyltransferase antibody
Terminal deoxyribonucleotidyltransferase antibody
Terminal transferase antibody
more
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Fig1: Western blot analysis on Jurkat using anti-TdT polyclonal antibody.
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