Anti-Autoimmune regulator antibody
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概述
- 产品描述The Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).
- 产品名称Anti-Autoimmune regulator antibody
- 分子量59 kDa
- 种属反应性Mouse
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cell nuclear, cytoplasm
- 其它名称AIRE antibody
AIRE_HUMAN antibody
AIRE1 antibody
APECED antibody
APECED protein antibody
APS1 antibody
APSI antibody
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody
Autoimmune regulator antibody
Autoimmune regulator protein antibody
PGA1 antibody
more
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应用
WB: 1:2,000
ICC: 1:500
IHC-P: 1:100
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Fig1: Western blot analysis on 293 cell (A) transfected and (B) none transfected with AIRE gene using anti-AIRE polyclonal antibody.
Fig2: Immunohistochemistry- staining AIRE in mouse thymus by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
Fig3: AIRE staining (red) in mouse embryonic stem cells (D3) by immunocytochemistry, nuclear staining with DAPI (blue) and SSEA-1 staining (green).
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