Anti-Netrin receptor DCC antibody
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概述
- 产品描述Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.
- 产品名称Anti-Netrin receptor DCC antibody
- 分子量90 kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cell membrane
- 其它名称Colorectal cancer related chromosome sequence 18 antibody
Colorectal cancer suppressor antibody
CRC 18 antibody
CRC18 antibody
CRCR 1 antibody
CRCR1 antibody
DCC antibody
DCC_HUMAN antibody
Deleted in colorectal cancer protein antibody
Deleted in colorectal carcinoma antibody
Immunoglobulin superfamily DCC subclass member 1 antibody
Netrin receptor DCC antibody
Tumor suppressor protein DCC antibody
more
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Fig1: Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
