Anti-LMNB2 antibody
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概述
- 产品描述Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD), which is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk.
- 产品名称Anti-LMNB2 antibody
- 分子量68 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Nucleus inner membrane
- 其它名称LAMB 2 antibody
LAMB2 antibody
Lamin-B2 antibody
LMN 2 antibody
LMN B2 antibody
LMN2 antibody
LMNB 2 antibody
LMNB2 antibody
LMNB2_HUMAN antibody
MGC2721 antibody
RGD1563803 antibody
more
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应用
WB: 1:1,000-1:2,000
ICC: 1:200
IHC-P: 1:200
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Fig1: Western blot analysis of Lamin B2 on different cell lysates using anti-LMNB2 antibody at 1/1000 dilution.
Positive control:
Lane 1: Hela
Lane2 :Jurkat
Lane 3: HepG2
Lane 4:Raji
Fig2: ICC staining of LMNB2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining of LMNB2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: ICC staining of LMNB2 in mouse embryonic stem cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig5: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti-LMNB2 antibody. Counter stained with hematoxylin.
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