Anti-IL-17 antibody
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概述
- 产品描述Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.
- 产品名称Anti-IL-17 antibody
- 分子量Predicted band size 17.5 kDa
- 种属反应性Human,Rat
- 验证应用WB,IHC-P,FC
- 抗体类型兔多抗
- 免疫原Peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Secreted.
- 其它名称CTLA 8 antibody
CTLA-8 antibody
CTLA8 antibody
Cytotoxic T lymphocyte associated antigen 8 antibody
Cytotoxic T lymphocyte associated protein 8 antibody
Cytotoxic T lymphocyte associated serine esterase 8 antibody
Cytotoxic T-lymphocyte-associated antigen 8 antibody
IL 17A antibody
IL-17 antibody
IL-17A antibody
IL17 antibody
IL17_HUMAN antibody
Il17a antibody
Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody
Interleukin 17A antibody
Interleukin-17A antibody
Interleukin17 antibody
Interleukin17A antibody
OTTHUMP00000016597 antibody
OTTMUSP00000046003 antibody
more
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应用
WB: 1:500-1:2000
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis of IL-17 on human fetal skeletal muscle tissue lysates using anti-IL-17 antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded rat heart tissue using anti-IL-17 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-IL-17 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human fetal skeletal muscle tissue using anti-IL-17 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-IL-17 antibody. Counter stained with hematoxylin.
Fig6: Flow cytometric analysis of Jurkat cells with IL-17 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
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