Anti-ADAM10 antibody
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概述
- 产品描述ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.
- 产品名称Anti-ADAM10 antibody
- 分子量84 kDa
- 种属反应性Human
- 验证应用WB,IHC-P
- 抗体类型兔多抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified
- 亚细胞定位Golgi apparatus. Plasma membrane.
- 其它名称A disintegrin and metalloprotease domain 10 antibody
A disintegrin and metalloproteinase domain 10 antibody
AD 10 antibody
AD10 antibody
AD18 antibody
ADA10_HUMAN antibody
ADAM 10 antibody
ADAM metallopeptidase domain 10 antibody
ADAM10 antibody
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MADM antibody
Mammalian disintegrin metalloprotease antibody
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应用
WB: 1:500-1:2,000
IHC-P: 1:50-1:200
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Fig1: Western blot analysis of ADAM10 on SiHa cell lysate using anti-ADAM10 antibody at 1/5,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-ADAM10 antibody. Counter stained with hematoxylin.
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