Anti-E3 ubiquitin ligase antibody
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概述
- 产品描述Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
- 产品名称Anti-E3 ubiquitin ligase antibody
- 分子量40 KDa
- 种属反应性Human,Mouse,Rat,Pig,Rabbit
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human E3 ubiquitin ligase/RNF218 51-150/352
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
- 其它名称C1orf166
E3 ubiquitin ligase
E3 ubiquitin protein ligase MUL1
FLJ12875
GIDE
Growth inhibition and death E3 ligase
MAPL
Mitochondrial anchored protein ligase
Mitochondrial ubiquitin ligase activator of NFKB 1
MUL1
MULAN
Putative NF kappa B activating protein 266
RING finger protein 218
RNF218
RP23-25C1.10-002.
more
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Fig1: Sample: Heart (Mouse) Lysate at 40 ug
Primary: Anti- E3 ubiquitin ligaseat 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution
Predicted band size: 40 kD
Observed band size: 40 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
