Anti-DR6 antibody
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概述
- 产品描述May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
- 产品名称Anti-DR6 antibody
- 分子量52/68 KDa
- 种属反应性Human,Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human DR6/CD358 101-200/655
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Membrane; Single-pass type I membrane protein (Probable).
- 其它名称TNFRSF 21
BM 018
BM018
CD358
Death receptor 6
DR 6
MGC31965
TNFR related death receptor 6
TNFRSF21
TNFRSF21 protein
TNR21_HUMAN
Tumor necrosis factor receptor superfamily member 21
Tumor necrosis factor receptor superfamily member 21 precursor.
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Fig1: Sample: Heart (Mouse) Lysate at 40 ug
Primary: Anti-DR6 at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
Fig2: Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-DR6 at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
