Anti-Bestrophin-1 antibody
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概述
- 产品描述This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.,
- 产品名称Anti-Bestrophin-1 antibody
- 分子量67 kDa
- 种属反应性Human, Rat, Mouse
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原Synthetic Peptide of Bestrophin-1
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2) antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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Fig1: Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using Bestrophin-1 Rabbit pAb diluted at 1:200.
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